About Us
Never Give Up
The Feliciano laboratory at Clemson University has been in operation for over a decade. The laboratory is an interdisciplinary group of scientists and clinicians focused on curing childhood diseases. The Feliciano laboratory is supported by the National Institutes of Health, Department of Defense, Whitehall Foundation, Tuberous Sclerosis Complex Alliance and others. The Feliciano laboratory has collaborated on projects to develop tools and techniques to aid in developing cures for neurological disorders. The laboratory uses a wide range of techniques that include next generation sequencing, single cell sequencing, confocal and multiphoton imaging, electron microscopy, biochemical techniques, and in vivo genetic manipulations. The Feliciano laboratory works with patient samples, animal models, and cell models. The Feliciano laboratory is assisted by a wide range of collaborations including the NIH Neurobiobank, Charles River Laboratories, Yale Transgenic Core Facility, Clemson Center for Human Genetics, the TSC Alliance Biosample Repository and others. The goal of the laboratory is to in translate basic scientific findings into clinically relevant ideas.
Our Story
The Feliciano Laboratory was founded in 2013. The Feliciano Laboratory has trained scientists and physicians from around the world. You can read about their findings by navigating to the Research Tab and reading their scientific manuscripts.
Members and Alumni
Around the Lab
Lab member presentations
Alumni Accomplishments
PLACES AND PRESENTS
INVITED LECTURES
Feliciano DM Harvard Medical School, Boston Children’s Hospital, Department of Pathology, How the Neonatal Subventricular Zone Relates to Neurodevelopmental Disorders, September 23, 2022Feliciano DM TSC-Associated Neuropsychiatric Disorders (TAND) international minisymposium, Tsc2 Shapes Molecular and Cellular Characteristics of Granule Cells, April 21, 2022 Feliciano DM TSC-Associated Neuropsychiatric Disorders (TAND) international minisymposium, Tsc2 Shapes Molecular and Cellular Characteristics of Granule Cells, April 21, 2022Feliciano DM A Tor of the Developing Brain South Carolina Autism and Neurodevelopmental Disorders (SCAND) Research Symposium March 05, 2021Feliciano DM C.S. Mott Center for Human Growth and Development, NIH Pregnancy and Perinatology Branch (PPB of NICHD), March 19-20, 2019Feliciano DM Cold Spring Harbor Asia, “Biology of Extracellular Vesicles”, Suzhou, China November 12-16, 2018Feliciano DM University of South Carolina, Department of Biology, “A Neural Stem Cell-Extracellular Vesicle-Microglia Axis”, September 2018Feliciano DM University of Georgia, Neuroscience Program, “A Neural Stem Cell-Extracellular Vesicle-Microglia Axis”, October 2018Feliciano DM Michigan State University (MSU), Department of Pediatrics, College Human Medicine, Invited Talk titled “Identifying Mechanisms and Therapeutic Approaches for Tuberous Sclerosis Complex and mTOR-Dependent Neurodevelopmental Disorders” June 26, 2017Feliciano DM, Morton MC, Neckles VN, Seluzicki CM, Neonatal subventricular zone neural stem cells release extracellular vesicles that function as a non-canonical microglial morphogen. Society for Neuroscience Postnatal Neurogenesis and Stem Cell Functions November 15, 2017 Invited Nanosymposium Oral PresentationFeliciano DM, Neurovesicles in Brain Development Southeastern Regional Developmental Biology Meeting May 19, 2017Feliciano DM, A neurodevelopmental regulator of the mtor pathway Society for Neuroscience Annual Meeting October 2015 Invited Nanosymposium Oral PresentationFeliciano DM, A neurodevelopmental regulator of the mtor pathway Society for Developmental Biology Southeast Regional Meeting, May 2015, Oral PresentationFeliciano DM University of Georgia at Athens (UGA), Department of Physiology and Pharmacology, mTOR Regulation and Cortical Development October 2016Feliciano DM Allen Brain Institute: Evolution of Cerebrocortical Development, 2013 Feliciano DM Saint Bonaventure University: Evolution of Cerebrocortical Development, 2013Feliciano DM University of New England: Pharmacologically Resistant Epilepsy: Lessons Learned from Tuberous Sclerosis Complex, 2013Feliciano DM Des Moines University: Molecular Mechanisms Regulating Fetal Brain Development and What we can Learn from Tuberous Sclerosis Complex, 2013Feliciano DM Tuberous Sclerosis Complex: Mouse Models and Mechanisms. 2012 Yale Department of PhysiologyFeliciano DM Single-cell knockout of Tsc1 in utero generates cortical tuber-like lesions and heterotopic nodules with cytomegalic neurons. 2011 Yale Club NeurobiologyFeliciano DM, Single-cell knockout of Tsc1 in utero generates cortical tuber-like lesions and heterotopic nodules with cytomegalic neurons. 2010 Society for Neuroscience Selected for Mini-symposium-Animal models of developmental disorders. Invited Oral PresentationFeliciano DM, Combining old and new tools to model malformations of cortical development, What’s Next: A Young Investigator Workshop. Invited Speaker at American Epilepsy Society 2011 Invited Oral PresentationConference Poster PresentationsPosters:International TSC Alliance, Tsc2 Regulates Differentiation. September 26, 2023 Riley VA, Shankar V, Holmberg JC, Sokolov AM, Neckles VN, Williams K, Lyman R, Mackay TFC, Feliciano DMSociety for Neuroscience, Tsc2 Shapes Molecular and Cellular Characteristics of Granule Cells, November 12-16, 2022, Jennie C. Holmberg, Victoria A. Riley, Aidan M. Sokolov, David M. FelicianoSociety for Neuroscience, Inactivating mutations in Tsc2 in inhibitory interneuron neuroprogenitors of the V-SVZ result in somatic mosaicism and the formation of SEGA-like hamartomas and striatal nodules, November 12-16, 2022, Victoria A. Riley, Jennie C. Holmberg, Aidan M. Sokolov, David M. FelicianoSoutheast Regional Society for Developmental Biology Conference 2022, June 01, 2022 -June 03, 2022, Determination of the effect of Tsc2 deletion on neurogenesis in the hippocampus, Melanie Garcia, Jennie C. Holmberg, Victoria A. Riley, David M. FelicianoSoutheast Regional Society for Developmental Biology Conference 2022, June 01, 2022 -June 03, 2022, Loss of Tsc2 in Late Inhibitory Neural Progenitors Causes Brain Lesion, Victoria A. Riley, Jennie C. Holmberg, Aidan M. Sokolov, David M. FelicianoCOBRE in Human Genetics Summer Symposium 2022, Tsc2 Shapes Molecular and Cellular Characteristics of Granule Cells, April 21, 2022, Jennie C. Holmberg, Victoria A. Riley, Aidan M. Sokolov, David M. FelicianoCOBRE in Human Genetics Summer Symposium 2022, April 21, 2022, Loss of Tsc2 in late inhibitory neural progenitors causes brain lesions Victoria A. Riley, Jennie C. Holmberg, Aidan M. Sokolov, David M. FelicianoCOBRE in Human Genetics Summer Symposium 2022, Determination of the Effect of TSC2 Deletion on Neurogenesis in the Hippocampus, April 21, 2022, Melanie Garcia, Jennie C. Holmberg, Victoria A. Riley, David M. FelicianoCOBRE in Human Genetics Summer Symposium 2022, Characterization of Microglia in Development and Disease, April 21, 2022, Victoria Neckles, Jennie C. Holmberg Victoria A. Riley, Aidan M. Sokolov, David M. FelicianoInternational TSC Research Conference 2021 (ITSCRC2021), A Mouse Model of Subependymal Giant Cell Astrocytomas, 17-19 June 2021, 2022, Victoria A. Riley, Aidan M. Sokolov, Jennie C. Holmberg, David M. FelicianoTSC-Associated Neuropsychiatric Disorders (TAND) international minisymposium, Loss of Tsc2 in late inhibitory neural progenitors causes brain lesions, April 21, 2022, Victoria A. RileyCOBRE in Human Genetics Summer Symposium 2022, Tsc2 Shapes Molecular and Cellular Characteristics of Granule Cells, April 21, 2022, Jennie C. Holmberg Victoria A. Riley, Aidan M. Sokolov, David M. FelicianoCOBRE in Human Genetics Summer Symposium 2022, Determination of the Effect of TSC2 Deletion on Neurogenesis in the Hippocampus, April 21, 2022, Melanie Garcia, Jennie C. Holmberg, Victoria A. Riley, Aidan M. Sokolov, David M. FelicianoCOBRE in Human Genetics Summer Symposium 2022, Characterization of Microglia in Development and Disease, April 21, 2022, Victoria Neckles, Jennie C. Holmberg Victoria A. Riley, Aidan M. Sokolov, David M. FelicianoSeluzicki, C.M., Holmberg, J.C., Morton M.C., Feliciano DM Slc7a5 Regulates Newborn Cortical Pyramidal Neuron mTOR Pathway Activity and Dendritogenesis March 2016 Neurogenesis (Organized by and contributions to the CSHL Press Monograph, Neurogenesis)Feliciano DM, Morton MC, Neckles VN, Seluzicki CM, Neonatal subventricular zone neural stem cells release extracellular vesicles that function as a non-canonical microglial morphogen. National Institutes of Health Extracellular RNA Communication Consortium 9th Investigators’ Meeting November 6-7, 2017Sokolov AM and Feliciano DM, mTOR-dependent ULK1 phosphorylation is rapamycin resistant in neural derived cells. Society for Neuroscience Annual Meeting Neurodevelopmental Disorders: Molecular and Cellular Mechanisms I Poster Session November 14, 2017Feliciano DM, Morton MC, Seluzicki CM, Holmberg, JC, A neurodevelopmental source of extracellular vesicles. Society for Neuroscience November 13, 2016.Morton MC, Holmberg JC, Cuffe SN, Kokolas A, Feliciano DM Inhibition of Neutral Sphingomeylinases Disrupts Embryonic Cortical Neurogenesis Society for Developmental Biology Southeast Regional Meeting, May 2015, PresentationTietje A, Maron K, Bordey A, Wei Y, Feliciano DM Temporal dynamics of cerebrospinal fluid vesicles. Society for Neuroscience Annual Meeting November 2014Feliciano DM, Quon JL, Bordey A Hif1a is a Tsc1 regulated factor required for newborn neuron survival, Cold Spring Harbor Laboratories, PTEN Meeting March 2012Feliciano DM, Taylor MM, Su T, Quon JL, Bordey A Focal Postnatal Tsc1 recombination in the Subventricular Zone induces mTOR pathway activation, reduces neuroblast migration rates, and generates ectopically localized neurons Drug Discovery Summit, Tuberous Sclerosis Alliance 2011Feliciano DM, Su T, Bordey A Single-cell knockout of Tsc1 in utero generates cortical tuber-like lesions and heterotopic nodules with cytomegalic neurons American Epilepsy Society 64th Annual Meeting 2010Feliciano DM, Su T, Bordey A Biallelic inactivation of TSC1 in radial Glia results in mTOR pathway activation Cold Spring Harbor Laboratories PTEN Meeting March 2010Feliciano DM, Su T, Platel JC, Bordey A Embryonic Single Cell Knockout of TSC1 recapitulates the phospho- S6 Giant Cell Phenotype of Tuberous Sclerosis Complex, Tuberous Sclerosis Alliance Meeting, October 2009Feliciano DM and Edelman AM CaMKIV Regulates Proliferation/Survival of Neuroblastoma Cells April 2008, ASPET Centennial Meeting
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